VISION IN THE FUTURE

EyeLief™

EyeLief™ is a preformed implant, composed of our photocrosslinked polymeric matrix that is designed to be injected into the eye through narrow gauge needles.

This implant is the first biodegradable implant that can achieve significant high loading of both small molecule and biologic drugs. In-vitro and animal studies have demonstrated sustained drug delivery for 4-9 months and safety of this implant. Unlike bulk degradation, EyeLief provides uniform implant degradation via erosion.

In preclinical studies the EyeLief implant demonstrated excellent tolerability following intravitreal and intracameral administration. In a six month safety and PK study there was no evidence of irritation or significant inflammatory response following intravitreal injection of the implant. Re-Vana is currently conducting additional preclinical tests and studies to enable the company to move to future human clinical trials.

Advantages of EyeLief™

  • Provides hydrophilic environment – ideal for maintaining protein/biologic stability
  • No significant drop in implant pH – provides improved protein/biologic stability
  • Sustained release molecules ranging from 4 – 9 months
  • High loading of biologics and small molecules by weight
  • Customized release profiles and release rates to address a wide range of clinical needs
  • Uniform biodegradation of the implants – erosion mechanism
  • Injected in the eye using narrow gauge needles – office based delivery
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